Step 1: PCB Wiring. The easy way out and to save hassles of soldering, you could probably use the Wemos's OLED Display addon. But the addon screen is just 0.66". There are larger displays availble, but you need to get your hands dirty and make the connections. The Wemos D1 Mini - OLED Display wiring is shown below.

About D1 Mini WeMos D1 Mini はESP8266モジュールを利用した、Arduino IDE利用可能な開発ボード。 WeMosには「D1 Mini」と「D1 R2」の2種類がある。使い方が同じ。 このシリーズは、コマンドラインで開発するPlatformIO環境を利用する。（GUIの開発環境Arduino IDEで開発する場合、WeMos (1) Blink を参照する…

I am completely new with I2C on ESPHome, especially trying to tie it into HA. Pretty much I am looking to have each key presented in HA as a binary sensor, and each neopixel as a light partition. I have my original macro keypad code based on individual pins, but have no clue where to begin for I2C.
This is a 2.4 inch TFT shield for a Wemos, its a large shield thats more than twice the size of a D1 mini but its an excellent little TFT screen and there are a couple of example to let you get up and running quick unlike some of the Arduino TFT shields which I have had trouble with in the past. This is a picture of the shield.
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The Wemos D1 Mini Boards have the interfaces I2C, SPI and UART. The Wi-Fi meets the specifications 802.11 b/g/n (2.4 GHz) with WPA/WPA2 PSK. The clock is 80 or 160 MHz. There are 11 I/O pins, all except D0 are PWM, I2C and One-Wire capable, I max is 12 mA. The maximum output voltage at the I/O pins is 3.3 volts.
The DS18B20 is a temperature sensor that can be used in various simple projects. This part uses the 1 wire (I2C) bus and you can connect multiple sensors up to your Arduino. The part is also relatively low cost and only requires an additional 4k7 pull up resistor. In the example below we shall make a basic example that reads the temperature and
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wemos d1 mini i2c example